• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    TRANSMISSION MECHANISM FOR A DOSE APPLICATION DEVICE. The invention relates to a transmission mechanism for a dose application device in which the dose can be selected by rotating a dose selection member (2.102), and through which the dose selection member (2.102) and a pressure button (4) rises from one end of the device in proportion to the selected dose from a fixed position in relation to a housing (1.101), whereby the injection of the selected dose can be applied by compressing the pressure button pressure back to its raised position by moving a piston rod (10, 110) that cooperates with the piston in a cartridge (12, 112) and expels a medicine out through a needle. The transmission mechanism is arranged in the device in such a way that the energy loss is very low.
    公开号:BR112013006410B1
    申请号:R112013006410-2
    申请日:2011-09-23
    公开日:2020-11-17
    发明作者:Claus Schmidt M0Ller
    申请人:Eli Lilly And Company；
    IPC主号:
    专利说明:

    Field of the Invention
    [001] The invention relates to a dose application device, in which a dose can be selected by rotating a dose selection member, by means of which a pressure button is raised from one end of the device, and the The selected dose can then be injected by compressing the push button back to its non-raised position, thereby moving a lead screw that cooperates with the piston in a cartridge and expels a drug out of the cartridge through a needle. Description of the Related Art
    [002] From patent document EP 0 327 910, an injection device is known in which a dose is selected by turning a tubular injection button that couples with a threaded lead screw, thereby making the injection button rise from the end of the injection device. When pressing the injection button down until it adheres to a fixed retainer, the threaded lead screw is moved a distance that corresponds to the movement of the injection button. The lead screw engages with a piston in a cartridge and the medication is expelled from the cartridge. This type of injection device transmits the injection force directly to the cartridge piston, but does not provide any transmission, that is, the linear movement of the injection button corresponds exactly to the linear movement of the lead screw.
    [003] Due to the directly transmitted injection force, a small dose of medicine causes a very small movement of the injection button and, therefore, it is advantageous to provide a transmission ratio between the injection button and the lead screw to leave more clear to the user whether the injection is advancing or not. Users who have reduced finger strength may at the same time want reduced injection strength to deliver an injection.
    [004] Patent document EP 1 568 389 describes a pen with a transmission mechanism and which has a very small loss of energy due to friction and thus a small injection force. A nut is rotated along a threaded lead screw. The nut is provided with a vertical transmission wheel with an axis perpendicular to the axis of the nut, which on one side engages with the housing and on the other side raises an injection button. When the injection button is pushed, the nut and lead screw are moved with a 2: 1 gear ratio between the injection button and lead screw. This mechanism provides very few surfaces that slide against each other and the loss of strength due to friction is therefore very limited. However, this mechanism is quite complicated and is not suitable for simple disposable dose delivery devices.
    [005] Patent document WO 2005/018721 describes a pen with a transmission mechanism based on a first and second threads that go in the same direction and a third thread on the lead screw that is not directly part of the transmission mechanism. A lead screw is connected with a nut. A non-rotating impeller is coupled with a selector through a first thread and the selector is coupled with the housing through a second thread. The pitch of the second thread is greater than the pitch of the first thread, and the difference between them is equal to the pitch of the lead screw. The impeller is also axially connected with the nut. When the dose selector is turned to adjust a dose, the nut and selector are rotated and the nut and impeller rise by a distance that corresponds to the amount of drug to be injected when the selector raises by a longer distance. When the selected dose is to be injected, the nut is rotated in the impeller. When the selector is pushed into the device, the rotation of the selector causes the non-rotating impeller to retract in the selector and the resulting displacement of the impeller to be equal to the selected dose. The nut is now pushed back to the zero position, bringing the lead screw with it and causing the insulin to be expelled.
    [006] In the device described in patent document W02009039851, the strength of the dose is very low due to a transmission mechanism comprising a transmission nut with a first thread that couples with the housing and a second thread that couples with an impeller, both with very large steps. The impeller is locked rotationally in the housing. The two threads go in opposite directions. The transmission ratio is calculated as the ratio between the two steps + 1, ((step 1 / step 2) +1). The transmission nut is axially connected to a metering nut that is threadably connected to a non-rotating lead screw. When a dose is selected, the dosing nut is turned and raised using a dose selector, but due to transmission the dose selector is raised even more by means of the impeller. The dose selector also acts as a push button. When the push button is pushed and the selected dose is injected, the impeller is lowered and the transmission nut is thus rotated between the impeller and the housing. This causes it to move axially, but for a shorter distance than the impeller. During the injection, the dosing nut is prevented from turning and the transmission nut now pushes the dosing nut and the lead screw, which causes the medication to be expelled. A selector is coupled to the dose selector when a dose is selected. When the dose is injected, the selector is uncoupled, and the selector is lowered by the impeller, which causes it to rotate due to a threaded coupling with the housing.
    [007] The above invention provides a convenient device with a very low dose force, but its production is quite complicated and the diameter for the sliding surfaces between the impeller and the selector is quite large, which makes it sensitive to friction.
    [008] An object of the invention is to provide a dose application device with a transmission mechanism which has a very low injection force, which is not sensitive to friction and which is suitable for automated assembly. Brief Description of the Invention
    [009] The objectives of the invention can be achieved by a dose application device comprising a housing, a dose selection system which also comprises a selector and a dose selection member and a dose injection system which also comprises a push button and a lead screw rotationally locked to the housing and a transmission mechanism. The transmission mechanism also comprises a first transmission member, an impeller connected to the first transmission member on a rail, allowing axial movement, and a second transmission member that is provided between the impeller and the first transmission member (this will be explained further below).
    [0010] The dose selection system is of a type in which a selector is coupled to the housing via a thread and rotationally coupled to a dose selection member when a dose is selected, and rotationally uncoupled when a selected dose is injected. The selector, impeller and dose selection member move up the same distance when a dose is selected. A dose is selected by rotating the dose selection member that carries the selector. During injection, the selector is detached from the dose selection member and lowered, which causes it to rotate due to the thread coupling with the housing. The sliding surfaces on the dose selection member and the selector are on top of the device and can therefore be very small in diameter and thereby cause very little loss of energy.
    [0011] The rotational coupling between the selector and the dose selection member is a ratchet that can be unidirectional or bidirectional. The torque between the parts due to the resistance in the ratchet must be higher than the torque due to the friction between the selector and the casing, as this will cause the dose selection member to carry the selector with it. During injection, the dose selection member does not rotate or rotates less than the selector and, while the selector is forced to rotate in its thread coupling with the housing, it causes the ratchet between the dose selection member and the selector close.
    [0012] In another mode, the connection between the selector and the dose selection member is a more rigid connection that comprises teeth in each part that can be coupled or uncoupled.
    [0013] The non-rotating lead screw cooperates with a piston in a cartridge. The lead screw is coupled with a metering nut via a thread with a pitch less than the thread between the selector and the housing. The dosing nut is rotationally locked in the transmission mechanism, which will be described further below. To adjust a dose, the dose selection member and the transmission mechanism are rotated, which causes the dosing nut to rise along the lead screw, but less than the elevation of the selector and selection member dose. When a dose is injected, the force applied to the pressure button is transferred to the dosing nut through the transmission mechanism which does not rotate during the injection. Since the dosing nut is locked rotationally to the transmission mechanism and consequently does not rotate during injection and also the lead screw is locked against rotation, the lead screw will be moved forward by the dosing nut, and the piston in the cartridge will expel the medicine.
    [0014] The transmission mechanism comprises a first (external) member and a second (internal) transmission member, and the dosing nut is rotationally connected to the first transmission member and axially connected to the second transmission member. The second transmission member comprises two threads that go in opposite directions, that is, one is a normal right-hand thread and the other is a left-hand thread. The thread to the right (or the thread to the left) is connected to the first transmission member, and the other thread is connected to the impeller which is rotationally locked to the dose selection member. The impeller and the first transmission member are rotationally locked together. When a dose is selected, the dosing nut forces the second transmission member to rise together with the dosing nut, and this will cause the second transmission member to rotate relative to the first transmission member due to the thread coupling. between them. This will cause the im-pulsor (and thus the dose selection member and the push button) to rise further, as it is directly affected by the elevation of the second transmission member and also by the relative rotation between the second transmission member and the impeller, which also causes the impeller to rise, since the thread runs in the opposite direction to the thread between the second transmission member and the first transmission member.
    [0015] Thus, when the first transmission member and the impeller are moved longitudinally in relation to each other, the second transmission member rotates and also moves longitudinally, but for a distance less than the distance moved by the push button . When the selected dose is injected, the force applied to the push button is transferred through the impeller to the second transmission member and also to the dosing nut and the lead screw. The steps in the second transmission member can be selected at any value, as long as the threads are not self-locking, since it is only the relationship between the steps that defines the transmission ratio. This means that the loss of force on the piston due to friction can be very low.
    [0016] When a dose is selected, a popping sound is produced. When the first transmission member is rotated, the ratchet arms on the first transmission member move radially inward and outward in the grooves in the housing.
    [0017] To prevent a dose from being selected that is larger than the contents remaining in the cartridge, the lead screw is not threaded at one end and the dosing nut, and thus the impeller and the dose selection member, therefore, they will be blocked against further rotation when the end of the thread on the lead screw is reached.
    [0018] It should be noted that the dose application device can be designed to be disposable or refillable and contain one, two or multiple cartridges at once. If the dose application device is designed to be refillable, the lead screw must be able to move backwards in the device when the cartridge holder is disconnected.
    [0019] In another embodiment, the first transmission member and the impeller are connected rotationally through a helical rail with a pitch greater than the threads on the second transmission member. This can make the relative rotation between the selector and the impeller less, since the impeller will rotate slightly during injection, and thus the energy loss will be less when the impeller lowers the selector during injection. If a very large transmission is desired, this also has the advantage that if the helical rail and the thread pitch between the impeller and the second transmission element go in the same direction, it can be prevented that the thread pitch becomes too high that the axial position of the second transmission element becomes inaccurate.
    [0020] The dosing nut can be connected rotationally to the first transmission member or the impeller.
    [0021] In another additional modality, the dosing nut is not present and the second transmission member with the two threads following in opposite directions is also coupling with the lead screw through a third thread. This is possible because the second transmission member rotates together with the entire transmission mechanism, as well as in relation to the first transmission member when a dose is selected, but only rotates in relation to the first transmission member when the dose is injected. . In this way, the second transmission member does not rotate the same number of turns with respect to the housing when a dose is selected and when a dose is injected. The thread coupling between the second transmission member and the lead screw must have a pitch of a size that ensures that the lead screw does not move axially when a dose is selected. The non-rotating connection between the lead screw and the housing can be replaced by a thread with the same pitch as between the first and second drive members to ensure that the lead screw and second drive member rotate together during injection . In this way it is ensured that a dose greater than the fluid remaining in the cartridge cannot be selected. Figures
    [0022] In the following, the invention is described in more detail with reference to the drawings, in which:
    [0023] Figure 1 shows a perspective view of an embodiment of a device according to the invention with a ratchet connection between the selector and the dose selection element,
    [0024] Figure 2 shows an exploded view of an embodiment of a device according to the invention with a ratchet connection between the selector and the dose selection element,
    [0025] Figure 3 schematically shows a vertical sectional view of a modality of a device according to the invention with a ratchet connection between the selector and the dose selection element and ready for the selection of a dose,
    [0026] Figure 4 schematically shows a vertical sectional view of an embodiment of a device according to the invention with a ratchet connection between the selector and the dose selection element and where a dose has been selected,
    [0027] Figure 5 schematically shows a vertical sectional view of an embodiment of a device according to the invention with a ratchet connection between the selector and the dose selection element and where the selected dose was injected,
    [0028] Figure 6 shows an exploded view of an embodiment of a device according to the invention with a tooth connection between the selector and the dose selection element,
    [0029] Figure 7 schematically shows a vertical sectional view of an embodiment of a device according to the invention with a tooth connection between the selector and the dose selection element and ready for the selection of a dose. Detailed Description
    [0030] Next, the term up refers to the direction towards the dose selection member 102 and the term down refers to the direction towards the end of the needle.
    [0031] Fig. 1 shows a device according to the invention in an oblique view. It is visible the casing 1 which comprises a window 16, where the quantity of a selected dose can be indicated, the dose selection member 2 through which a dose is selected, the push button 4 through which a selected dose is injected, and the cartridge holder 3 which comprises a thread for fixing a double-ended needle. The cartridge holder 3 contains the cartridge loaded with medicine 12 (see Fig. 2). The cartridge 12 comprises a piston (see Fig. 3), which cooperates with the advance screw 10 of the injection system to expel a selected dose of medication from the cartridge 12 out through the needle. The cooperation between the different elements of the device will be described below.
    [0032] As shown in Fig. 3, a dosing nut 9 is coupled with a lead screw 10 via a thread connection 34/35 (the thread 34 on the lead screw visible in Fig. 2). The lead screw 10 is locked against rotation with respect to housing 1 via a 13/36 key / groove connection. The dosing nut 9 is rotationally locked on a first transmission member 6 (key / groove connection 31/32, see Fig. 2) which is rotationally locked on an impeller 8 and a dose selection member 2, and the impeller 8 is attached to the dose selection member 2 so that they act as a piece. The first transmission member 6 has a number of projections 29 (see Fig. 2) on the bottom that cooperates with the grooves 14 in the housing 1 so that when the dose selection member 2 is rotated, the first transmission member 6 is positioned in certain positions evenly spaced around the turn, and a popping sound is produced at the same time when a dose is selected.
    A transmission mechanism comprises the first transmission member 6, a second transmission member 7 and the impeller 8 and is located between the dosing nut 9 and the dose selection member 2 in such a way that, when the dose selection member 2 is being rotated for dose selection, the dosing nut 9 also rotates, and this raises the dosing nut 9 due to the 34/35 thread coupling with the lead screw 10, but the impeller 8 and the dose selection member 2 are raised by a greater distance due to the transmission mechanism. The transmission mechanism is provided to make it easier to inject a selected dose, to make it more visible to the user that the push button is being moved during the injection, and to provide more space for numbers to be written in a selector 5.
    [0034] The second transmission member 7 is axially connected to the dosing nut 9, but can rotate in relation to the dosing nut 9. This can be seen in Fig. 3. There are two threads on the outer surface of the second transmission member 7 , which go in opposite directions, that is, one of them is a normal right-hand thread and the other is a left-hand thread. The right hand thread is coupled with the first transmission member 6 and the left hand thread is coupled with the impeller 8. When a dose is selected, the dosing nut 9 forces the second transmission member 7 to rise along with the dosing nut 9 due to the axial connection and this will cause the second transmission member 7 to rotate due to the thread coupling 27/39 with the first transmission member (see Fig. 3). This will cause the impeller 8 to rise more than the second transmission member 7, since it is affected in two ways: it is raised axially by the second transmission member 7 and is rotated in the 24/26 thread coupling between the two elements. Due to the fact that the thread goes in the opposite direction to the 27/39 thread connection between the second transmission member 7 and the first transmission member 6, this will cause the impeller 8 to rise further.
    [0035] This means that when the first transmission member 6 and the impeller 8, which are rotationally locked via the key / groove connection 23/33, are moved axially relative to each other, the second transmission member 7 rotates and moves axially a distance less than the distance axially moved by the impeller 8. When a dose is injected, the force applied to the pressure button 4 is transferred to the dosing nut 9 through the dose selection member 4 of the impeller 8 and the second transmission member 7. A distance transmission is achieved when the impeller 8 moves a longer distance than the metering nut 9 and the lead screw 10, and a transmission in force is obtained, once that the loss of force due to friction is less than the extra force due to transmission.
    [0036] The threads pitch on the second transmission member 7 can be adjusted to any value, as long as the threads are not self-locking and can therefore be selected to be very high. This is very advantageous, as it means that the loss of dosage force due to friction can be very low.
    [0037] The directions of the two threads on the double nut can be interchanged, so that the thread to the right is to the left, and vice versa. The important thing is that they go in opposite directions.
    [0038] In order to display the quantity of a selected dose, a selector numbered 5 is part of the device. This can be seen more clearly in Fig. 3. Selector 5 mates with housing 1 through a 15/17 thread connection. Selector 5 has two ratchet arms 18 that interact with teeth 20 on the inner cylindrical surface of dose selection member 2. When dose selection member 2 is rotated to select a dose, the ratchet arm 18 rotates the selector 5 is with me because the resistance between the dose selection member 2 and the selector 5 due to the ratchet arms 18 is greater than the resistance in the thread between the selector 5 and the housing 1 due to friction. When a selected dose is corrected, dose selection member 2 is rotated in the locking direction of a ratchet arm 18, and selector 5 rotates together.
    [0039] To reduce the energy loss between the selector 5 and the dose selection member 2 even further when a dose is injected, the connection 23/33 between the impeller 8 and the first transmission member 6 can be formed as a helical rail with a pitch greater than the steps of the second transmission member 7. This will cause dose selection member 2 to rotate slowly when a selected dose is injected and, if the direction of rotation is arranged to be the same direction than that for selector 5, the relative movement between selector 5 and dose selection member 2 will be less and the energy loss will be correspondingly reduced. The thread pitch 26 on the second transmission member 7 and the number of increments between housing 1 and first transmission member 6 have to be corrected accordingly to make this mode work. Further corrections of the parts will also be necessary.
    [0040] Fig. 3 shows a device ready for selecting a dose. To select a dose, the dose selection member 2 is rotated, which causes the device to make a popping sound for each increment due to the locking protrusions 29 in the first transmission member 6 that cooperate with the grooves 14 in the housing 1, where each click corresponds, for example, to a medication unit in the cartridge. In addition, this interface will provide a number of preferred dose selection member positions. The dose selection member 2 rotates the impeller 8 and the first transmission member 6, and this will now raise the dosing nut 9 (rotationally locked on the first transmission element 6 via the 31/32 key / groove connection). a zero position. The impeller 8 also rises, but because of the transmission mechanism it rises more than the dosing nut 9. The selector 5 is rotated together with the dose selection member 2 due to the coupling with the ratchet arms 18 in the selector 5 and rises a distance that corresponds to the lift of the impeller 8.
    [0041] In Fig. 4 a dose has been selected and the device is ready to inject. Dose selection member 2, impeller 8 and first transmission member 6 have been rotated and it can be seen clearly that selector 5, impeller 8, dose selection member 2 and push button 4 have moved by one distance, and that the second transmission member 7 and the dosing nut 9 have moved another short distance.
    [0042] In Fig. 5 the selected dose was injected. Push button 4 was pushed, which lowered impeller 8 and rotated and moved down second transmission member 7. However, second transmission member 7, dosing nut 9 and lead screw 10 moved down by a distance less than that of the push button 4, the impeller 8 and the dose selection member 2. The selector 5 was lowered and turned back to the zero position and a popping sound was produced due to the interaction between the teeth 20 inside the dose selector 2 and the ratchet arms 18 in the selector 5. The thrust force is provided through a sliding surface 37 in the dose selection member 2. Once this connection is at the end of the pressure of the device and above the impeller, can be located in a very small diameter with a very small loss of energy as a consequence. This is very advantageous. It can be seen that the lead screw 10 has moved a distance that corresponds to the movement of the dosing nut 9 when the dose has been selected. Consequently, the piston washer 11 and the piston in the cartridge also moved and the medication was expelled.
    [0043] Figures 6 and 7 show another embodiment according to the invention with a helical rail between the first transmission member 106 and the impeller 108, with a release link between the selector 105 and the selection member dose 102 and with dose selection member 102 also acting as a push button. As can be seen in Fig. 7, the dosing nut 109 is coupling with the lead screw 110 through a threaded connection 134/135 and is connected axially, but not rotationally with the second transmission member 107 and connected rotationally but not axially with the first transmission member 106 through the teeth 131 in the dosing nut 109 and in the grooves 132 inside the first transmission member 106. The lead screw 110 is locked against rotation with respect to the housing by a locking piece 147 fixed in housing 101 in which lead screw 110 can slide down without turning. Thread 127 on second transmission member 107 is coupling with thread segments 139 on first transmission member 106 and thread 126 on second transmission member 107 is coupling with thread segments 124 on impeller 108. The first transmission member 106 and the impeller 108 are also connected via a helical rail 123 in the impeller 108 and in the rail segments 133 in the first transmission member 106 (the respective threads and the rails can be better visualized in Fig. 6). The first transmission member 106 can rotate with respect to housing 101, producing a popping sound by means of a latch protrusion 129 that cooperates with the teeth 114 in a locking sleeve 146 fixed in housing 101 (best seen in Fig. 6 ). A connector 142 is axially connected to dose selection member 102 and rotationally connected to impeller 108 via keys on connector 142. Dose selection member 102 and connector 142 are attached together and can move axially for a short distance and by means of this movement the teeth 143 in the dose selection member 102 disengage from the teeth 149 in the numbered selector 105 and the teeth 144 in the connector 142 disengage from the teeth 150 in the numbered selector 105. A spring 140, a spring 141 and dose selection member 102 are connected with selector 105 and connector 142 in such a way that spring 140 and spring bushing 141 will attempt to push selector 105 back into coupling with the dose selection member 102 and connector 142. A flange 152 on impeller 108 is attached to selector 105 in such a way that only rotational movement between the two parts is permitted and in such a way that selector 105 cannot be pushed too far in relation to the injection. The selector 105 is coupled through a threaded connection 115/117 which couples with a threaded element 145 which is fixed in the housing 101.
    [0044] When the dose selection member 102 is rotated for the selection of a dose the selector 105 is also rotated due to the coupling of teeth 143/149 between the parts. The 144/150 tooth coupling between selector 105 and connector 142 ensures that connector 142 is also rotated and thus also impeller 108 and first transmission member 106, however, first transmission member 106 rotates less than that the impeller 108 due to the helical passage connection 123/133 between the two parts and the relative axial movement between them. The first transmission member 106 will produce a popping sound during dose selection and index the dose selection in specific positions that correspond to the specific amounts of drug due to the cooperation of protuberance 129 in the first transmission member 106 with teeth 114 inside locking collar 146. The metering nut 109 and the second transmission member 107 will be raised due to the thread coupling between the metering nut 109 and the lead screw 110, and this will rotate the second transmission member 107 due to the coupling. 127/139 thread with the first transmission member 106. The impeller 108 will now be pushed up and rotated upwards by the second transmission member 107 due to the 124/126 thread connection between them and consequently will move up higher than the dosing nut 109 and the second transmission member 107. The selector 105 will move up the same distance as the impeller 108 due to the 115/117 thread connection with the threaded element 145 fixed in the housing 101.
    [0045] When dose selection member 102 is pushed and the selected dose is injected, dose selection member 102 and connector 142 are decoupled from selector 105. After connector 142 has reached the end of the key connection / groove with impeller 108, impeller 108 is pushed down. The first transmission member 106 does not rotate during injection and the impeller 108 and connector 142 rotate slightly. The second transmission member 107 will be pushed down by the impeller 108 but, due to the two threads in opposite directions 126/127 on the second transmission member 107 which are coupling with the thread segment 139 on the first transmission member 106 and the transmission segment thread 124 on impeller 108, will move a shorter distance. The first drive member 106 and the dosing nut 109 do not rotate during injection so that when the dosing nut 109 is pushed down it also pushes the screw down. ”No« o ,,, 1.0. - .. ..to p. and the piston in cartridge 112 and the drug will be expelled through the needle.
    权利要求:
    Claims (7)
    [0001]
    1. A dose delivery device, comprising: a transmission mechanism including a first transmission member (6, 106) with a first thread (39, 139), an impeller (8, 108) with a second thread (24, 124), a second transmission member (7, 107), a housing (1, 101) to interface with a user and in which the transmission mechanism is arranged coaxially, a dose selection member (2,102), and one lead screw (10,110), where the first (39, 139) and second (24, 124) threads follow in opposite directions, and where the first transmission member (6, 106) and the impeller (8, 108) ) are rotationally connected via a rail (33, 123) that allows axial movement, characterized by the fact that: the second transmission member (7, 107) comprises two threads (26/27, 126/127) that engage the first (39, 139) and second (24, 124) threads, the dose delivery device further comprises a metering nut (9, 109) engaged with the lead screw (10, 110) through a thread (34/35, 134/135), the dosing nut (9, 109) axially connected to the second transmission member (7,107), the dosing nut (9, 109) is connected rotationally to the first transmission member (6, 106), the dose selection member (2, 102) is rotationally connected to the transmission mechanism during dose selection, and the transmission mechanism rotates in relation to the housing (1, 101 ) when a dose is selected by rotating the dose selection member (2, 102).
    [0002]
    2. Device according to claim 1, characterized by the fact that the rail (33, 123) between the first transmission member (6, 106) and the impeller (8, 108) does not allow the rotation movement between the parts.
    [0003]
    3. Device according to claim 1, characterized by the fact that the rotational connection between the first transmission member (6, 106) and the impeller (8, 108) is a helical rail (33, 123).
    [0004]
    4. Device according to any one of the preceding claims, characterized in that a selector (5, 105) that is threadably coupled with the housing (1, 101) is rotated together with a dose selection member ( 2, 102) when a dose is selected, and does not rotate with the dose selection member (2, 102) when the dose is injected.
    [0005]
    5. Device according to any one of the preceding claims, characterized by the fact that the selector (5, 105) is connected to the dose selection member (2, 102) via a one-way ratchet (12/20) .
    [0006]
    6. Device according to any one of the preceding claims, characterized by the fact that the lead screw (10,110) is locked rotationally in the housing (1, 101).
    [0007]
    7. Device according to claim 1, characterized by the fact that the dose selection member (2, 102) is rotationally connected to the impeller (8, 108) during dose selection
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    EA024223B1|2016-08-31|
    引用文献:
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    法律状态:
    2018-12-26| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-09-10| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-07-14| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2020-11-17| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/09/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    2021-08-24| B25A| Requested transfer of rights approved|Owner name: CLAUS SCHMIDT MOELLER (DK) |
    2021-09-14| B25A| Requested transfer of rights approved|Owner name: CPU INNOVATION APS (DK) |
    优先权:
    申请号 | 申请日 | 专利标题
    DKPA201000872|2010-09-24|
    DKPA201000872|2010-09-24|
    PCT/DK2011/000103|WO2012037938A1|2010-09-24|2011-09-23|A gearing mechanism for a dose delivery device|
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